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Generation and repair of AID-initiated DNA lesions in B lymphocytes
null
《医学前沿(英文)》 2014年 第8卷 第2期 页码 201-216 doi: 10.1007/s11684-014-0324-4
Activation-induced deaminase (AID) initiates the secondary antibody diversification process in B lymphocytes. In mammalian B cells, this process includes somatic hypermutation (SHM) and class switch recombination (CSR), both of which require AID. AID induces U:G mismatch lesions in DNA that are subsequently converted into point mutations or DNA double stranded breaks during SHM/CSR. In a physiological context, AID targets immunoglobulin (Ig) loci to mediate SHM/CSR. However, recent studies reveal genome-wide access of AID to numerous non-Ig loci. Thus, AID poses a threat to the genome of B cells if AID-initiated DNA lesions cannot be properly repaired. In this review, we focus on the molecular mechanisms that regulate the specificity of AID targeting and the repair pathways responsible for processing AID-initiated DNA lesions.
关键词: class switch recombination somatic hypermutation activation-induced deaminase DNA repair genomic instability
Leijing Liu, Hao Zhang, Bo Xiao, Yang Liu, Bin Xu, Chen Wang, Shanpeng Wen, Erjun Zhou, Gang Chen, Chan Im, Wenjing Tian
《化学科学与工程前沿(英文)》 2021年 第15卷 第1期 页码 127-137 doi: 10.1007/s11705-020-1936-7
关键词: third component organic solar cells charge carrier generation charge carrier recombination bimolecular recombination
Low crosstalk switch unit for dense piezoelectric sensor networks
Lei QIU, Shenfang YUAN,
《机械工程前沿(英文)》 2009年 第4卷 第4期 页码 401-406 doi: 10.1007/s11465-009-0047-4
关键词: structural health monitoring (SHM) piezoelectric (PZT) sensor networks switch unit crosstalk signal
Multi-class dynamic network traffic flow propagation model with physical queues
Yanfeng LI, Jun LI
《工程管理前沿(英文)》 2017年 第4卷 第4期 页码 399-407 doi: 10.15302/J-FEM-2017041
关键词: first-in-first-out (FIFO) multi-class traffic physical queues traffic flow modeling
A survey of instantaneous poles for a class of two-degree-of-freedom spherical mechanisms
Soheil ZARKANDI
《机械工程前沿(英文)》 2014年 第9卷 第4期 页码 344-353 doi: 10.1007/s11465-014-0320-z
This paper is a detailed exploration of instantaneous poles for a class of two-degree-of-freedom (two-DOF) spherical mechanisms (SMs) with seven links or bars. For two-DOF SMs, the secondary instantaneous poles (the ones which cannot be found by direct inspection) must lie on the specified great circles. For many of these mechanisms, however, some of these great circles cannot be obtained by a direct application of Aronhold-Kennedy theorem. This paper presents geometrical and analytical techniques to locate these unknown great circles for three topologies of seven-bar two-DOF SMs.
关键词: spherical mechanisms instantaneous poles Aronhold-Kennedy theorem great circles pencil of meridian
Shiyan ZHENG
《能源前沿(英文)》 2011年 第5卷 第4期 页码 367-375 doi: 10.1007/s11708-011-0170-x
关键词: internal combustion engine irreversibility power output efficiency optimization
Nitin NAMPALLI,Tsun Hang FUNG,Stuart WENHAM,Brett HALLAM,Malcolm ABBOTT
《能源前沿(英文)》 2017年 第11卷 第1期 页码 4-22 doi: 10.1007/s11708-016-0442-6
关键词: Czochralski silicon boron-oxygen defect injection dependent lifetime spectroscopy goodness-of-fit repeatability error
肖文,欧阳芳锐,王先甲
《中国工程科学》 2004年 第6卷 第7期 页码 48-52
提出了城市供水系统产权结构重组的两种基本模式,运用制度经济学和管理学理论,提出产权结构模式评价的指标与方法,分析了这两种产权结构模式的特性和在这两种模式下不同利益主体的行为与利益关系的变化特点及优缺点,并提出了缓解劣势的手段与方法。
Highlights in agri-product quality and safety
Guanghong ZHOU
《农业科学与工程前沿(英文)》 2018年 第5卷 第3期 页码 289-290 doi: 10.15302/J-FASE-2018236
The advances of Sino-German new materials
Rongbiao Wang
《化学科学与工程前沿(英文)》 2018年 第12卷 第3期 页码 327-328 doi: 10.1007/s11705-018-1748-1
Xiaodong JIN, Yuefa FANG, Dan ZHANG, Xueling LUO
《机械工程前沿(英文)》 2020年 第15卷 第1期 页码 66-80 doi: 10.1007/s11465-019-0570-x
关键词: parallel mechanism redundant mechanism large rotational angles machine tools 2R1T spindle head collaborative manipulator
Evaluation of transmissibility for a class of nonlinear passive vibration isolators
Z. K. PENG, Z. Q. LANG, G. MENG
《机械工程前沿(英文)》 2012年 第7卷 第4期 页码 401-409 doi: 10.1007/s11465-012-0349-9
In this study, the concept of Output Frequency Response Functions (OFRFs) is applied to represent the transmissibility of nonlinear isolators in frequency domain. With the OFRFs estimated from numerical simulation responses, an explicit analytical relationship between the transmissibility and the nonlinear characteristic parameters is derived for a wide class of nonlinear isolators that have nonlinear anti-symmetric damping characteristics and a comprehensive pattern about how the nonlinear damping characteristic parameters might affect the force and displacement transmissibility is built for the vibration isolators. The results reveal that it is reasonable to analyze the force and displacement transmissibility of the nonlinear isolators by simply investigating the fundamental harmonic components of the force and displacement outputs of the nonlinear isolators, and the introduction of a nonlinear anti-symmetric damping into vibration isolators can significantly suppress both the force and displacement transmissibility over the resonant frequency region, but has almost no effect on the transmissibility at non-resonant regions. These conclusions are of significant importance in the analysis and design of the nonlinear vibration isolators with nonlinear anti-symmetric damping.
关键词: nonlinear vibration volterra series Output Frequency Response Functions (OFRFs) nonlinear damping vibration isolator
reference tracking control design for a class of nonlinear systems with time-varying delays
Mei-qin LIU,Hai-yang CHEN,Sen-lin ZHANG
《信息与电子工程前沿(英文)》 2015年 第16卷 第9期 页码 759-768 doi: 10.1631/FITEE.1500053
关键词: H∞ reference tracking Nonlinear system State feedback control Time-varying delays Unified model
Synthesis and properties of tetrathiafulvalene-porphyrin assemblies
Meijiang LI, Rui HUANG, Changzhi WU, Hujin ZUO, Guoqiao LAI, Yongjia SHEN
《化学科学与工程前沿(英文)》 2011年 第5卷 第4期 页码 422-428 doi: 10.1007/s11705-011-1124-x
关键词: tetrathiafulvalene tetraphenylporphyrin dyad triad fluorescence molecular switch
Technical innovation for Sanyang Road Cross-river Tunnel Project
Yu ZHONG
《工程管理前沿(英文)》 2018年 第5卷 第3期 页码 411-415 doi: 10.15302/J-FEM-2018206
标题 作者 时间 类型 操作
Effects of BTA2 as the third component on the charge carrier generation and recombination behavior of
Leijing Liu, Hao Zhang, Bo Xiao, Yang Liu, Bin Xu, Chen Wang, Shanpeng Wen, Erjun Zhou, Gang Chen, Chan Im, Wenjing Tian
期刊论文
Multi-class dynamic network traffic flow propagation model with physical queues
Yanfeng LI, Jun LI
期刊论文
A survey of instantaneous poles for a class of two-degree-of-freedom spherical mechanisms
Soheil ZARKANDI
期刊论文
Unified cycle model of a class of internal combustion engines and their optimum performance characteristics
Shiyan ZHENG
期刊论文
Statistical analysis of recombination properties of the boron-oxygen defect in p-type Czochralski silicon
Nitin NAMPALLI,Tsun Hang FUNG,Stuart WENHAM,Brett HALLAM,Malcolm ABBOTT
期刊论文
Design and analysis of a class of redundant collaborative manipulators with 2-dimension large rotational
Xiaodong JIN, Yuefa FANG, Dan ZHANG, Xueling LUO
期刊论文
Evaluation of transmissibility for a class of nonlinear passive vibration isolators
Z. K. PENG, Z. Q. LANG, G. MENG
期刊论文
reference tracking control design for a class of nonlinear systems with time-varying delays
Mei-qin LIU,Hai-yang CHEN,Sen-lin ZHANG
期刊论文
Synthesis and properties of tetrathiafulvalene-porphyrin assemblies
Meijiang LI, Rui HUANG, Changzhi WU, Hujin ZUO, Guoqiao LAI, Yongjia SHEN
期刊论文